Causes and types of angioedema

Angioedema is a medical condition that causes swelling under the skin in the deeper layers of skin. There are a few different causes and types of angioedema. Hereditary angioedema (HAE) is caused by a genetic deficiency of C1 inhibitor, a protein that regulates inflammation. It is estimated to affect about 1 in 10,000 to 1 in 50,000 people worldwide. Another type is acquired angioedema due to medications like ACE inhibitors. Angioedema may also be triggered by allergic reactions to certain foods, insect bites, medications, latex or other allergens.

Symptoms include swelling of the face, lips, mouth, tongue, larynx (voice box), abdomen or limbs. The swelling develops rapidly and may feel tight. Skin over the swollen area may become painful or tender. Other symptoms depend on the location of swelling, but can include difficulty breathing, speaking, swallowing or gastroinstetinal pain.

Diagnosis and evaluation

If someone experiences recurring or unexplained Angioedema Treatment episodes, seeing an allergist or immunologist is recommended. Blood tests can help determine the underlying cause and rule out other conditions. If HAE is suspected, a laboratory test can confirm a C1 inhibitor deficiency. The doctor will also consider your symptoms and medical history. Additional testing like laryngoscopy may be done if throat swelling is involved to evaluate airway swelling. Keeping a detailed symptom diary can help the doctor assess triggers and develop a treatment plan.

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