Cremagel is used for the treatment of anal fissures (tear in the lining of the anus). It relaxes the smooth muscles around the anus and promotes blood flow to the lining of the anus. This way it helps wound healing and reduces the associated symptoms. Cremagel is for external use only. Clean and dry the affected area and gently apply it over the affected area. It is advised to use it in the dose and duration as advised by your doctor. Limit physical exercises, standing, and prolonged sitting while on medication. The most common side effects are application site reactions (burning, irritation, itching, and redness), dizziness, rectal bleeding, and headache. There are other, rarer side effects, some of them serious. Ask your doctor and read the leaflet which comes with the medicine to make sure you are keeping safe.