Zhewitra, which contains vardenafil as its active ingredient, is used to treat erectile dysfunction. Like tadalafil in Tazzle, vardenafil is also metabolized by the enzyme CYP3A4. Grapefruit and grapefruit juice can inhibit this enzyme, leading to higher concentrations of vardenafil in the bloodstream. This interaction can increase the risk of side effects and adverse reactions. This can be particularly problematic for individuals taking other medications that lower blood pressure or those with cardiovascular conditions. https://www.flatmeds.com/product/zhewitra-20-mg/