Pyruvate locates an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanine. It can be converted by the pyruvate dehydrogenase complex to acetyl CoA, which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, steroids, and ketone bodies depending on the tissue and metabolic state in which it is formed. It also has a critical role in balancing the energy needs of various tissues in the body. Abnormalities in pyruvate metabolism are associated with various diseases, such as pyruvate dehydrogenase complex deficiency and pyruvate carboxylase deficiency. Pyruvate metabolism analysis with the help of highly sensitive analytical tools is a powerful way to diagnose and gain new insights into disease mechanisms and treatments. pyruvate metabolism https://metabolomics.creative-proteomics.com/pyruvate-metabolism-service.htm