Peyronie’s disease is a condition in which scar tissue, called plaque, forms on the penis and causes penile curvature during erections. This scar tissue often forms on the top or bottom of the penis, which causes the penis to bend or curve during erections. Peyronies disease can significantly impact a man’s self-confidence and sexual function. While the exact cause of Peyronie’s disease is unknown, some of the risk factors include injury to the penis, diabetes, Dupuytren’s contracture, and smoking.

Non-Surgical Peyronies Disease Treatment

Oral Medications

Some of the oral medications that are used to treat Peyronie’s disease include:

– Vitamin E: Vitamin E is an antioxidant that may help reduce inflammation and the formation of scar tissue. Doses of 400-1200 IU per day are commonly prescribed.

– Collagenase Clostridium Histolyticum (Xiaflex): Xiaflex is an enzyme injected directly into the plaque that causes it to gradually soften and reduce curvature over the course of treatment. Multiple injections are required over several months. Common side effects include pain, bruising and swelling at the injection site.

– Potaba (Potassium Para-Aminobenzoate): Potaba is thought to enhance oxygen and nutrient delivery to tissues and prevent plaques from worsening. Doses of 9-15g per day are used for 6-12 months. Common side effects are nausea, diarrhea and flatulence.

– Medications for Penis Traction Therapy: For some men, penis traction therapy using devices like the PeniMaster or SizeGenetics can help straighten the penis over months of use. Medications like pentoxifylline or tamoxifen are sometimes prescribed to aid the effects of traction therapy.

Lifestyle Changes

Making lifestyle changes such modifying one’s diet and reducing weight if obese, quitting smoking and limiting alcohol intake may help Peyronies Disease Treatment from progressing. Stretching and massage therapy have also shown some benefits, though more research is still needed.

Surgical Treatment Options

Inflated Penile Prosthesis Implantation: For men with Peyronie’s disease that causes severe penile curvature preventing intercourse, an inflatable or malleable penile implant may be considered. This effectively straightens the penis and allows an erection, though it requires major surgery.

Plaque Incision and Grafting (PICG): This involves making one or more cuts in the penile plaque and using grafted tissue like skin to fill in the gaps. This technique attempts to straighten the penis, but erections are initially painful as the wounds heal. Long term bending can still potentially recur.

Plaque Excision and Partial Penectomy: For severe cases, the fibrous plaque causing curvature can be entirely excised although this risks shortening the penis permanently. Partial penectomy may also be needed to achieve straightening but sacrifices some penile length.

Penile Lengthening Surgery: If Peyronies disease has caused penile shortening along with curvature, penile lengthening techniques like shaft elongation can potentially be combined with other surgical options. However, significant post-operative recovery and risks apply.

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