Creative Biostructure offers a range of customized solutions to help you succeed in the hit identification process. Our team will design a strategy for the project based on the nature of the project and the information available and the approaches we provide can be applied individually or in parallel. Hit Discovery https://drug-discovery.creative-biostructure.com/hit-identification-p20

As a structure-based drug discovery CRO, Creative Biostructure not only provides experimental techniques to determine the structure, but also utilizes high-performance computing tools to predict the structural model of the target molecule, collect information about dynamic properties, and predict binding patterns and affinity between target proteins and other interacting molecules. Target Modeling https://drug-discovery.creative-biostructure.com/structural-modeling-of-target-molecule-p16

As a leading service provider in the field of structural biology, relying on the first-class structural biology technology platform that covers X-ray crystallography, cryo-electron microscopy (Cryo-EM) technology and protein NMR spectroscopy, Creative Biostructure provides a comprehensive solution of target structure determination, called MagHelix™ Gene-to-Protein and Gene-to-Structure, complemented with the most advanced biophysical methods to characterize target and target-ligand interaction. Our services support structure-guided lead discovery and optimization, as well as biological drug discovery, such as therapeutic antibody discovery. Target Cryo-EM https://drug-discovery.creative-biostructure.com/maghelix-gene-to-protein-and-gene-to-structure-p15

Lead discovery and optimization play a crucial role to determine the quality of clinical candidates. After this process, a set of compounds can be screened that interact with the target and the confirmed hits have specific activity against the target. Creative Biostructure performs comprehensive lead discovery and optimization solutions including library construction, library screening (in silico, in vitro and in vivo), hit-to-lead optimization and preclinical evaluation, etc. Lead Optimization https://drug-discovery.creative-biostructure.com/lead-discovery-and-optimization-p19

Coronaviruses (CoVs) pose a major threat to public health security because no drugs or vaccines are currently approved for the treatment of human CoVs. With the continuous outbreak of SARS-CoV-2 (novel coronavirus, formerly 2019-nCoV), how to rapidly develop therapeutics to prevent and control Coronavirus Disease 2019 (COVID-19) has become a hot issue of global concern. And the outbreak will intensify efforts by the biomedical industry to research and develop drugs for infectious diseases. As a leading provider of contract research services for structural biology projects, Creative Biostructure is committed to structural and computational drug discovery against targets to facilitate the development of antiviral drugs for human CoVs. SARS-CoV-2 Drug Development https://www.creative-biostructure.com/coronavirus/antiviral-drug-discovery-services-for-coronavirus-p10.htm

Since the outbreak of novel coronavirus (SARS-CoV-2) in various regions of the world, the research and development (R&D) of small-molecule drugs and biologics targeting novel coronavirus have been intensified and achieved some breakthroughs. The selection of the correct antigen is one of the most critical steps in a successful antibody development project. Drawing on our expertise in protein structural biology, Creative Biostructure currently provides custom antigen design and preparation services for the therapeutics development for coronavirus infection. Based on the application of antibodies, we will comprehensively consider many factors such as homology, molecular weight, purity, length, hydrophilic, and structure to help you design and prepare the optimal antigen. Coronavirus Antigen Preparation https://www.creative-biostructure.com/coronavirus/antigen-design-and-preparation-services-for-coronavirus-p19.htm

As an expert in data analysis, Creative Biostructure is helping our customers with genomic data analysis services for coronavirus research. We have rich experience in solving special analyses of various viral genomes, and our customer-centric bioinformatics analysis team guarantees high-quality analytical data for customers worldwide. Coronavirus Genome Analysis https://www.creative-biostructure.com/coronavirus/advanced-genome-mining-for-coronavirus-p44.htm

A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) modeling as a rational drug design tool has received extensive attention from pharmaceutical scientists and many ADMET-related prediction models have been developed. The low-cost and high-throughput characteristics of these models allow for a more simplified drug development process in which the drug accessibility of compounds can be predicted, and the identification of hits and structural optimization can be guided. Creative Biostructure is a trusted partner in the development of antiviral drugs for coronavirus infection, and we can support ADMET modeling and profiling. COVID-19 ADMET Profiling https://www.creative-biostructure.com/coronavirus/admet-modeling-and-profiling-p32.htm

At Creative Biostructure, we have the most advanced high-resolution electron microscopy equipment and a direct electron detector. Our services include the preparation and purification of bacteriophages, image processing of Cryo-EM, and finally we provide our customer with the three-dimensional (3D) reconstruction and near atomic model of bacteriophages. The ultrastructure of bacteriophage can eventually gain an insight into antibacterial research. Bacteriophage structure service https://www.creative-biostructure.com/Cryo-EM-for-Bacteriophages-600.htm

Creative Biostructure enables to advance 3D cryo-electron microscopy (cryo-EM) into antigen-antibody complex applications for drug discovery. 3D cryo-EM enables the structure determination of large protein complexes like antigen-antibody complexes, or membrane proteins. We expertise in protein production and proprietary expression and cell culture tools, including antigen-antibody complexes, make proteins of highest quality available. Your target of choice can be produced at Creative Biostructure and subsequently analyzed with cryo-EM for 3D reconstruction or epitope mapping applications. Antigen-antibody Complex Structure service https://www.creative-biostructure.com/Cryo-EM-for-Antigen-antibody-Complex-595.htm