QuickBooks Error 15222 typically occurs when there’s an issue with the QuickBooks update or when the program can’t connect to the Internet. This error can result from conflicts with Internet Explorer or issues with QuickBooks update settings. To resolve it, you may need to update Internet Explorer, reset Internet settings, or manually update QuickBooks. For assistance, contact QuickBooks support at 1.855.738.2784 for expert help and troubleshooting.