COVID-19 live updates: Total number of cases passes 129 million

The coronavirus outbreak began in Wuhan, China, in December 2019.
Known as SARS-CoV-2, the virus has resulted in more than 127 million infections and more than 2.7 million deaths.
SARS-CoV-2 infection causes a respiratory illness called COVID-19.
COVID-19 has now been reported on every continent.
Keep up to date with the latest research and information about COVID-19 here.
For vaccine information, visit our live vaccine updates article.

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Andrew Redington/Getty Images
The coronavirus outbreak began in Wuhan, China, in December 2019.
Known as SARS-CoV-2, the virus has resulted in more than 127 million infections and more than 2.7 million deaths.
SARS-CoV-2 infection causes a respiratory illness called COVID-19.
COVID-19 has now been reported on every continent.
Keep up to date with the latest research and information about COVID-19 here.
For vaccine information, visit our live vaccine updates article.
03/29/2021 11:59 GMT — Limited protection against SARS-CoV-2 reinfection in over 65s

A recent study suggests that a first infection with SARS-CoV-2 provides only 47% protection against a second infection for those aged 65 years and over, compared with 80% protection across all age groups.

The findings underscore the importance of physical distancing and vaccination, even among people who have already had COVID-19.

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n a recent opinion feature, researchers from Vanderbilt University in Nashville, TN, explain why COVID-19 policies in the United States should explicitly consider implications for men’s health during the pandemic.

Read the article here.

03/25/2021 12:25 GMT — New SARS-CoV-2 variant carrying a double mutation

Scientists in India have identified a number of COVID-19 cases caused by a SARS-CoV-2 variant carrying two mutations in the spike protein. It is currently unclear if this variant is more infectious or causes more severe disease. 

According to the BBC, the variant was present in 20% of cases in the Indian state Maharashtra, which has recently experienced a steep rise in new cases.  

One of the variant’s mutations, E484Q, is similar to E484K. This mutation is familiar from variants that researchers in South Africa and Brazil have found. 

The other mutation, L452R, is also present in variants of the B.1.427/B.1.429 lineage. Scientists in the United States identified this variant of concern, and some people refer to it as the “California variant.” 

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This, they explain, might have provided an incomplete view of the efficacy data.

Dr. Peter English, a retired consultant in communicable disease control says: “There is a single sentence behind this story: ‘The DSMB expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data.’ I find this problematic in various ways. It reads like a sentence from the conclusions of a paper but one that has been presented out of context, without any explanation of the reasons for drawing the conclusion or of what they think the consequences might be.”

He continues: “If you present data, stating the period in which the data were collected, how can the data be ‘outdated’[?] The AstraZeneca press release did say it was on ‘interim’ data. There may be more recent data, but that would not normally outdate or invalidate the interim results.”

Dr. English calls the National Institutes of Health (NIH) communication “shamefully bad” and worries that it might increase vaccine hesitancy.