Missing an American Airlines flight can be stressful, therefore, you are looking for Does American Airlines charge for missing a flight? Whether American Airlines charges for missing a flight depends on the reasons and circumstances surrounding the miss. So, these are cited below, must get it:

American Airlines typically doesn't charge a specific "missed flight fee" if you miss your flight without canceling it beforehand.
If your flight is canceled or delayed, causing you to miss your connection, American will rebook you on the next convenient flight at no additional cost. It applies to both American Airlines and partner airline flights.
If American Airlines cancels your flight or significantly delays it, you can choose a full refund instead of rebooking. In this case, you won't be charged any fees.
If you miss your flight for a reason and want to rebook on a different flight, you might be charged a change fee, depending on the fare type and availability.
Depending on the new flight you choose, you might also need to pay the difference in fare if it's higher than your original ticket.
If you are a no-show for your flight without notifying American Airlines, you won't get a refund for the remaining part of your itinerary. Additionally, any future travel vouchers associated with the ticket might be canceled.
If American Airlines delays your flight significantly (usually 3 hours or more), you might be eligible for compensation depending on the specific circumstances and distance of the flight.
If your flight departs from an EU country and gets canceled or significantly delayed, you might be entitled to compensation under EU regulations, regardless of the reason for the disruption.
 

Hence, by learning about the American Airlines charge for missing flights, you can use American Airlines last minute flight deals, which you will get by calling the customer service agent.