NFL picks and predictions for Week 2 of the season are much le s of a crapshoot than they were for opening weekend given the newfound knowledge we have about all 32 teams, but we're not about to suggest that there are any sure bets.

If anything, teams like the Colts and Eagleslast week reinforced the fact that even some of the biggest favorites based on the odds can lose. Now some contenders are flirting with a damning 0-2 hole to start the 2020 NFL season.

Based on the odds, Week 2 is expected to be a big one for the home teams, as the road team is favored in just five of the 16 games on the schedule. And of the games that feature home favorites, several of them have been set with point spreads that suggest the game is all but a to s-up.

With that as the background, below are our picks and predictions for Week 2 of the NFL season. As always, ourpoint spreads are courtesy of .

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NFL picks, predictions for Week 2 The Jon Berti Jersey referenced media source is mi sing and needs to be re-embedded.Cincinnati Bengals at Cleveland Browns()

Thursday, 8:20 p.m. ET, NFL Network

At the risk of overreacting to a solid debut for Joe Burrow, we can't help but trust him more than Baker Mayfield in this game given what the latter showed us last week to start his third NFL season. The Browns suddenly are in the rare "must-win" spot in Week 2; if they lose to the Andre Dawson Jersey Bengals, their season could quickly fall into the tank. The good news for Cleveland is that Mayfield is just one many players and coaches who are feeling the same pre sure. They have no choice but to respond.

Pick: Browns 21, Bengals 17

Atlanta Falcons at Dallas Cowboys ()

Sunday, 1 p.m. ET, Fox

This is another matchup of teams trying to avoid the dreaded 0-2 hole. The Cowboys, though, have many more positives to take away from their Week 1 lo s than the Falcons do. Matt Ryan should be able to exploit some favorable matchups again, but Dak Prescott and the Cowboys' offense this week don't have to deal with the game-wrecker that is Aaron Donald.

Pick: Cowboys 34, Falcons 27

The referenced media source is mi sing and needs to be re-embedded.Denver Broncos at Pittsburgh Steelers ()

Sunday, 1 p.m. ET, CBS

Both of these teams are playing on short weeks, which in theory works in favor of the team that doesn't have to deal Kyle Barraclough Jersey with travel. The Steelers have realistic title aspirations in 2020 with Ben Roethlisberger back in the lineup to support a dominant defense. The Broncos are not yet on that level, especially without their best player, Von Miller.

Pick: Steelers 28, Broncos 17

Los Angeles Rams at Philadelphia Eagles ()

Sunday, 1 p.m. ET, Fox

This matchup makes the Eagles' Week 1 clunker against Washington much worse, because the level of difficultyrises significantly against the Rams. If Washington was able to sack Carson Wentz eight times, what are we supposed to expect Aaron Donald and Co. to do? If the Eagles' defense can get the Rams' offense off schedule, Philly will have a good chance to win. If not, it's an 0-2 start for the defending NFC East champs.

Pick: Rams 27, Eagles 21

The referenced media source is mi sing and needs to be re-embedded.San Francisco 49ers() at New York Jets

Sunday, 1 p.m. ET, Fox

Overreactions to Week 1 results are common, and suggesting the defending NFC champions are in trouble because they lost their seasonopener to a division rival is certainly an overreaction. Suggesting the Jets are still bad does not feel like an overreaction. Adam Gase's team needs to flip that perception quickly before things get nasty in New York, but that's unlikely to happen in Week 2.

Pick: 49ers 30, Jets 20

Detroit Lions at Green Bay Packers ()

Sunday, 1 p.m. ET, Fox

As tempting as it might be, and even though everybody else is doing it, the Packers can't look at the Lions as the "same old Lions" after Detroitgifted Chicago a win last week. This is still a tricky division game against a team that had reasonable expectations Jonathan Villar Jersey for 2020 but was embarra sed in Week 1. The better team should still win even if the game iscloser than expected.

Pick: Packers 26, Lions 23

The referenced media source is mi sing and needs to be re-embedded.Minnesota Vikingsat Indianapolis Colts ()

Sunday, 1 p.m. ET, Fox

The Colts getting a field goal at home makes this a to s-up game in the eyes of oddsmakers, which seems reasonable for a contest featuring a pair of contenders who suffered disappointing results in Week 1. The Vikings, though, lost to a much better team than the Colts did. They also have more stability at quarterback and betterhealth in the running game.

Pick: Vikings 30, Colts 24

New York Giants at Chicago Bears ()

Sunday, 1 p.m. ET, CBS

We doubt lightning will strike twice, so if the Bears fall behind in this game, don't expect Mitchell Trubisky to get his team back into contention by making big throw after big throw. This will be more about coach Matt Nagy's offense running on schedule against a defense it can manage.

Pick: Bears 26, Giants 20

The referenced Jazz Chisholm Jersey media source is mi sing and needs to be re-embedded.Buffalo Bills () at Miami Dolphins

Sunday, 1p.m. ET, CBS

Many subscribe to the theory that legitimate contenders need to win all of the games they're supposed to win. So here's the second consecutive chance for the Bills to prove their legitimacy in 2020 to that crowd. Chances are they won't have a problem doing Blank Jersey to the Dolphins almost exactly what the Patriots did in Week 1.

Pick: Bills 21, Dolphins 10

Carolina Panthers at Tampa Bay Buccaneers()

Sunday, 1 p.m. ET, Fox

Carolina's offense looked good in the first game of the Matt Rhule/Joe Brady era, but there's a significant difficulty increase from Las Vegas' defense to that of Tampa Bay. And that young Panthers defense that couldn't keep a Derek Carr-led offense out of the end zone enough? Meet Tom Brady.

Pick: Buccaneers 35, Panthers 24

Jacksonville Jaguars at Tenne see Titans ()

Sunday, 1p.m. ET,CBS

The Gardner Minshew magic was impre sive in Week 1 as the Jags upset the Colts, but Indianapolis didn't exactly help itself with a pair of costly turnovers. The Titans are le s likely to throw the game away and more likely to give Minshew trouble in the pa sing game.

Pick: Titans 24, Jaguars 17

Washington Football Team at Arizona Cardinals()

Sunday, 4:05 p.m. ET, Fox

Who had these two teams being undefeated in Week 2? Both are riding the highs of their respective Week 1 upsets, but Washington feels l