Use of instruments in chemistry is a must since the scientist uses his/her knowledge in determining the various characteristics of the compound or elements present and thus is able to identify the most appropriate instrument to use in carrying out a particular task. This essay aims to discuss LC/MS instrumentation as the toolkit I have used recently and relate its usefulness to an experiment I have performed in the past. Liquid Chromatography/Mass Spectroscopy instrumentation is the instrument I used in my summer internship. The device is modern and combines the capabilities of Liquid Chromatography in physical separation and the Mass Spectrum mass analysis capabilities. It has been effective in measuring of molecule’s weight as well as determining whether the molecule is pure or not. One of the many types of research I was involved in the past in that I strongly feel that Liquid Chromatography /Mass Spectroscopy could have been more useful is the Hepatitis B Viruses (HBV) dissertation. The main aim of the study was to find out the most suitable molecule for the HBV biological activity. Most of the scan instruments I was using were not accurate and efficient enough, and this got me thinking of the most suitable device I could use. I spent most of my time on reading patents and journals with the purpose of being able to manage to come up with the best activity compound. I tried to modify the structures of all the compounds that I had known to come up with the new structure of HBV, but the exercise was time-consuming and too tedious. I had not gained much knowledge on the date about other instruments that I could have used till just recently when I have finally come to learn about Liquid Chromatography /Mass Spectroscopy method. It was neither easy nor efficient to use another instrument at that time for the attainment of the right and proportionate compound required, since there was a greater need to find out the correct mass and purity of the compound at the same time. The use of Liquid Chromatography /Mass Spectroscopy could have made the research much easier by delivering the most desirable results in the best way possible besides being faster. The process could have been easier and more accurate if I had used Liquid Chromatography /Mass Spectroscopy, since the compound I was to submit needed to be pure, and even though I had performed better in the biological test line, I still failed in the final delivery of the research. This idea is to mean that even if I used other instruments and managed to get the best compound, I would be forced to use Liquid Chromatography /Mass Spectroscopy to check the purity of the compound further before the submission of my research so as to get the best results. There are plenty of scan instruments to be used in this activity but as I have come to realize, Liquid Chromatography /Mass Spectroscopy is precise and accurate in giving the desired outcome of both the compounds’ mass and purity. It is easy to use and also reliable in providing details of how much analyte is required in the formation of an individual known compound. Conclusively, my recent instrumental experience has been an eye-opener in that I come to discover an instrument that is so crucial and efficient in the field of chemistry. Liquid Chromatography /Mass Spectroscopy is the combination of the two instruments thus making its relevance in chemistry not only important but dependable. The experience, therefore, broadened my knowledge of the subject. About the author: Jessica King is working as a writer at Exclusivethesis - the service where all of you can buy a dissertation on a very different themes.